Loop diuretics differ in chemical structure from each other. Furosemide, bumetanide, azosemide, piretanide, tripamide contain a sulfonamide group; ethacrynic acid - a derivative of phenoxyacetic acid, a different structure in muzolimine. Torsemide is a sulfonylurea derivative. Currently, furosemide, bumetanide, ethacrylic acid and torsemide are used. Here, we are going to have a closer look at the distinctive features of Torsemide and Lasix (Furosemide).
What is Torsemide?
To get rid of edema, symptomatic manifestations of diseases such as renal, hepatic or heart failure, diuretic drugs will help. Among others, highly active are loop type diuretics, to which Torsemide also belongs. Drug administration is also prescribed for patients with high blood pressure, nephrogenic diabetes insipidus, and for preventing the development of urolithiasis in idiopathic hypercalciuria.
Diuretic has a wide list of contraindications and side effects, that's why the attending physician must prescribe a drug and monitor the patient's condition - this will ensure the desired result and prevent undesirable consequences of self-medication.
Torsemide acts in the loop of Henle (the ascending section of the nephron loop) and prevents reabsorption - the inverse absorption of ions of minerals such as chlorine and sodium into the blood of the ions, and the excretion of potassium also increases. This diuretic begins to function after approximately 1 hour, the maximum diuretic effect is achieved over the next 2-3 hours, and after 4 hours the drug is excreted from the body almost completely.
In people with abnormalities in the liver or kidney, heart failure, the process of half-elimination of the metabolites of Torsemide (intermediate products of metabolism in living cells) takes place a little longer, but the accumulation of a substance in the body is unlikely. However, it is important to remember that Torsemide and its metabolites are almost not produced during hemofiltration or hemodialysis procedures.
Difference between Furosemide and Torsemide
Torsemide, like all loop diuretics, inhibits the reabsorption of sodium and chlorides in the ascending part of the Henle loop, but unlike furosemide, it also blocks the effects of aldosterone, that is, to a lesser extent enhances renal excretion of potassium. This reduces the risk of developing hypokalemia - one of the main unwanted drug reactions of loop and thiazide diuretics.
The main advantage of Torsemide is the presence of a gum-containing envelope, which slows the release of the active substance, which reduces fluctuations in its concentration in the blood and, therefore, provides a more stable and long-lasting effect. The pharmacokinetic properties of torsemide differ from furosemide.
The pharmacokinetics of torsemide and its metabolites are characterized by linear dependence. This means that its Cmax in the blood serum and the area under the curve of serum levels increases in proportion to the dosage. The final half-life (T1) of torsemide and its metabolites in healthy people is 3-4 hours. The total clearance of torsemide is 40 ml / min, the renal clearance is about 10 ml / min.
In healthy people, approximately 80% of the administered dose is excreted in the form of torsemide and its metabolites with urine with such an average percentage: torsemide - about 24%, M1 metabolite about 12%, M3 metabolite about 3%, metabolite M5 - about 41%.
Torsemide is metabolized by cytochrome P450, which explains the absence of changes in its pharmacokinetic properties in patients with heart failure or chronic kidney disease. Only 25% of the dose is excreted in the urine unchanged (against 60-65% when taking furosemide).
In this regard, the pharmacokinetics of torsemide is not significantly affected by renal function, while the half-life of furosemide is increased in patients with renal insufficiency. The action of torsemide, like other loop diuretics, begins quickly. The dose of torasemide 10-20 mg is equivalent to 40 mg of furosemide. With an increase in dose, a linear increase in diuresis and sodium naresus was observed.
Torsemide is the only diuretic, the effectiveness of which is confirmed in large multicenter studies.
Torsemide advantages over Furosemide
Loop diuretic Torsemide is characterized by high bioavailability and prolonged effect, which causes a number of favorable pharmacodynamic properties of the drug. Torsemide has a pronounced antihypertensive effect; It can be used in patients with arterial hypertension both in the form of monotherapy, and in combination with other antihypertensive agents.
The advantages of Torsemide over Furosemide in the treatment of patients with chronic heart failure, including in terms of prognosis, have been proven in large studies.
The pharmacokinetic properties of torsemide practically do not change with chronic hepatic and renal insufficiency. Side effects of the drug are quantitatively and qualitatively comparable with those of other diuretics. All this makes torsemide worthy of wider application in modern, clinical practice.
The received research data show us that torsemide therapy more effectively and safely improves the clinical status of the patient, thereby reducing the number of inpatient hospitalizations, and also has a more favorable prognosis in patients with CHF, which directly reflects the pharmacoeconomic benefit for the state in the treatment of patients with CHF the original long-acting loop diuretic – torsemide.
How to buy Furosemide or Torsemide online?
You can buy either Furosemide or Torsemide without a prescription online. Internet pharmacies sell both of the mentioned drugs over the counter. Before you buy either Furosemide or Torsemide, you are recommended to read the instructions carefully and ask all questions you have. The customer support online will come the rescue round the clock.
Hope that the article was helpful for you to make the right choice of the diuretic. However, it is recommended to get the professional consulatation taking into account your individual health condition and drug intolerance. Buying Furosemide or Torsemide online, you will save much time and money as the price is several times lower compared to the one you have to pay when buying the same quality drugs at your local pharmacy.
Fill out a simple order form and submit it. You will get the chosen drug without delay. No need to worry about the details you are asked to provide via the site because the SSL protocol protects the provided information.
Choose the necessary drug dosage, compare their pharmacological action, and give preference to the one you don't have contraindications to. They have similar lists of contraindications and side effects, however, they are based on different active susbtances. This means that you should make sure that you can tolerate any ingredient in the drug composition.