Lasix (Furosemide) diuretic tablets are prescribed to eliminate edema of various etiologies. This drug is aimed at removing excess fluid from the body and increasing the production of urine. To avoid undesirable negative consequences in the treatment of Furosemide, taking a diuretic is necessary after getting the professional medical advice.
Diuretic Furosemide activates renal work to excrete large volumes of fluid and salts in urine. This action of the drug allows patients to get rid of edema that have arisen for various reasons. But, unfortunately, along with the excreted urine from the body come out the ions of potassium and magnesium. That's why profile specialists recommend taking potassium-sparing preparations with Furosemide. The severity of diuretic action of the described drug depends on the dosage that patients take but in any case this diuretic is more powerful than thiazide-like diuretics.
Is Lasix Good for Edema?
To understand the reason for the effectiveness of diuretic appointment Lasix in edema, it is necessary to have an idea of what constitutes the edema itself. As you know, the supply of oxygen and nutrients to all tissues of the human body is responsible for blood. Therefore, it constantly moves through the vessels, where it is pumped by the heart. Reaching to the smallest vessels - the capillaries - the blood interacts with the cells.
This contact is due to the fact that the blood pressure in the capillaries is higher than in the intercellular space, and therefore, due to the special device of the capillary wall, the liquid part of the blood "seeps" there from the arterial end of the tiny vessel.
Back to the vascular bed from the interstitial space, the fluid comes in because of the reduced pressure in the venous end of the capillary. Normally, the processes of fluid entering the tissue and its reverse absorption (reabsorption) are balanced, balance each other, but when the balance is formed, edema is formed.
Thus, the physical essence of edema lies in the fact that excess fluid accumulates in the tissues. Eliminate these excesses helps nothing more than the appointment of a diuretic in swelling. Lasix has a pronounced diuretic action. The diuretic effect of the drug is achieved by blocking the reverse absorption of sodium and chlorine.
Furosemide penetrates the renal tubule, in particular to its loop-like part (Hegel loop) and there blocks the reabsorption of Na. Increasing the release of sodium ions entails an increased release of liquid, potassium, calcium and magnesium. With the intravenous injection of the injection solution, the diuretic effect is observed after 5 minutes and lasts for two hours.
When taking Lasix in tablets diuresis occurs within an hour and lasts about seven hours. The hypotensive effect of the drug comes as a result of an increase in the release of sodium chloride (salt) and prevention of vasoconstriction due to a decrease in the volume of circulating blood. Hypotensive effect is more effective when administered intravenously.
Lasix quickly enough reduces arterial pressure, and also pressure in the left ventricle and a pulmonary artery, expands large veins and thus reduces preload of heart. With intravenous administration, the pressure decreases after 5-10 minutes, in the case of using the drug in tablets, the pressure returns to normal within an hour and remains within the normal 2-3 hours.
How Do You Treat Pulmonary Edema with Furosemide?
Treatment of patients with pulmonary edema should be aimed at eliminating or significantly reducing the effect of those underlying causes that led to the development of this complication. Therefore, first of all, measures are needed to reduce the flow of blood to the lungs, which can be achieved using vasodilator drugs, diuretics, harnesses, or bloodletting.
If there are indications at the same time, it is necessary to provide the conditions for improving the outflow of blood from the small circle, which is achieved by means that increase the contractile capacity of the heart and improve metabolic processes in the myocardium, as well as reducing peripheral vascular resistance and, thereby, facilitating the work of the heart.
It should also take measures aimed at sealing the alveolar-capillary membranes, increasing filtration back pressure, increasing the surface tension of the foam, providing the body with oxygen, reducing the effect of biologically active substances.
To start treatment of patients with pulmonary edema that are conscious, is most expedient with the application of measures aimed at normalizing the emotional background of the patient, eliminating the response to a stressful situation, which, as already mentioned, often becomes a trigger mechanism for the development of pulmonary edema.
The importance of sedative therapy in the management of pulmonary edema is very high. With the use of sedatives, the content of catecholamines in the blood is normalized, and consequently, the peripheral vascular spasm decreases, the blood flow to the lungs decreases and the work of the heart is facilitated, which improves the outflow of blood from the small circle and reduces the filtration of tissue fluid through the alveolar-capillary membrane.
With the use of these drugs, shortness of breath decreases, which contributes, in particular, to a decrease in blood flow to the lungs (the action of the thoracic pump) and normalization of the back pressure of filtration in the lungs, since a significant rarefaction developing at inspiratory height in the alveoli decreases. In addition, against the background of the action of sedative drugs, the intensity of metabolic processes decreases, which facilitates the tolerance of the lack of oxygen.
To reduce BCC, discharge the small circle of blood circulation and dehydration of the pulmonary parenchyma, diuretics should be used. The best preparation of this group is Lasix (furosemide), which at a dose of 20-40 mg should be administered intravenously. The therapeutic effect of furosemide is due to its diuretic activity: the effect develops in a few minutes and lasts 2 -3 hours with the release of up to 2 liters of urine.
A distinct decrease in the volume of plasma and an increase in the colloid osmotic pressure due to blood thickening cause the transition of edematous fluid to the vascular bed, leading to a decrease in pressure in the pulmonary artery and blood filling of the lungs, thereby reducing the effective filtration pressure.
A similar property is possessed by ethacrynic acid (uretite) - 50-100 mg. With a sharp violation of hemodynamics (shock, paroxysmal tachycardia), the use of diuretics is indicated only after the normalization of blood pressure.
Furosemide for Postpartum Edema
Almost every woman worries that she has swelling during pregnancy and after childbirth. Calm down, this is normal. Almost every pregnant woman suffers from swelling. This is normal condition during pregnancy due to hormonal changes in the background. Swelling after childbirth takes place in a few days, depending on the accumulated fluid in the body of a woman for pregnancy.
If you are not pregnant the second time and your blood pressure is normal, then swelling after childbirth is not a disease and they do not need medication in most cases.
The fluid that accumulates during pregnancy is excreted by urination. Remember that after giving birth, you often go to the toilet, which means that your kidneys are involved in the process of removing excess fluid after delivery from your body. Furosemide (Lasix) acts quickly, with intravenous administration - for several minutes, which allows using it in emergency situations (pulmonary edema, brain, etc.).
With prolonged use of Furosemide (in tablets), it is also necessary to add products containing potassium to the food. The efficacy of Furosemide in the treatment of patients with circulatory insufficiency is also associated with a direct dilating effect on peripheral vessels. Usually, take 1 tablet (0.025 g) per day in the morning, with insufficient effectiveness - 2 tablets (0.08 g) in the morning.
During pregnancy, Furosemide is used in severe gestosis - severe swelling, a significant increase in blood pressure. As a rule, treatment is performed in a hospital.
What if Lasix not working for Edema?
The fluid retention in the body occurs for various reasons. Inflammatory diseases of the urinary system, heart failure, impaired function of the endocrine system, inflammation of the gallbladder, eating salty foods, menopause and many other causes are the causes of edema. The diuretic does not help in all cases equally. For example, drugs effective for fluid retention due to heart failure may be useless in venous stasis.
In some cases, patients with heart failure, taking loop diuretics (Furosemide) as prescribed by the doctor, do not get the desired effect. When the diuretic does not work, the therapist should pay attention to the pH of the urine and adjust the treatment. For acidification of urine, patients are prescribed a short course of Diacarba, which changes the pH of urine and increases the diuretic effect of other drugs.
It is also worth noting that there is a law of diuretic power. The closer they get to the kidney, the stronger the diuretic effect. From this it follows that the most powerful are looped, less pronounced effect is observed in thiazide (Hypothiazide) drugs. The weakest effect is possessed by potassium-sparing drugs (Veroshpiron). That is why a diuretic does not work in cases where a fast effect is needed.
There is another reason for inefficiency. For some reason, patients take medication without a doctor's prescription and a specific schedule for taking the tablets. This can for some time increase the amount of excreted urine. But then what happens to the body if diuretics are not taken regularly?
The neurohormonal profile will begin to swing and the effect of taking medications will disappear. If diuretics do not help, then it's worth to see a doctor. Taking medication should be in a daily regime and only in adequate doses prescribed by the doctor.
Often, inadequate intake of drugs leads to a violation of the sodium-potassium balance. The body begins to hold all the forces to the liquid, accumulating it in the intercellular space. To prevent this from happening, patients along with diuretics are prescribed potassium-sparing drugs.
The admission of only thiazide drugs with heart failure may lead to a deterioration in the filtration processes in the kidneys. In order to prevent impaired kidney function, a combination of several diuretics (for example, loop and thiazide) is prescribed.
Can Lasix Increase Potassium?
With the intake of the vast majority of diuretics and decoctions, a significant amount of potassium is removed from the body together with other salts. Replenish its deficiency is possible having the proper nutrition or drugs in the form of tablets, which can restore the balance as quickly as possible.
Most of the potassium is contained in the cells that make up any organism. A small amount of it is in the intercellular fluid. In the intercellular space, it is responsible for the passage of nerve impulses, monitors the contraction of muscles, including the heart muscle, maintains the level of blood pressure.
Intracellular potassium regulates acid-alkaline and water balance, participates in the work of nerve cells of the brain, interacts with enzymes. If you do not restore the balance of this element after taking diuretics, its deficiency can bring the body to neuroses, cause serious problems with the heart, and subject a stroke.
Natural losses of potassium in the body occur with the isolation of stomach acid during digestion of food. Part of the potassium is lost when sweating intensively in the heat or during exercise. The part is excreted through the kidneys. The greatest amount of the element can be washed away with the onset of the administration of certain diuretics. There are drugs that practically do not affect the output of potassium, for example, trifas, and there are those that have a significant impact on its balance in the body.
The diuretic effect of diuretics from the group of thiazides (hydrochlorothiazide, furosemide) is constructed on the withdrawal from the body of sodium, after the water is removed from the sodium. But in addition to sodium, these diuretics also excrete potassium. Blood pressure mediators usually give a diuretic effect simultaneously, but they have a mechanism for potassium storage, so it is not recommended to take potassium preparations at the same time to avoid intoxication from an overdose of this element.
Another nuance is associated with the presence of magnesium in the body. Deficiency of magnesium does not allow to assimilate potassium and prevents the restoration of the balance of this element in the body. Keep track of the magnesium level, try to make it up if necessary, then taking potassium-containing drugs will give the desired effect.
In normal conditions, when you do not suffer from kidney disease, hypertension, edema of various nature, you do not exercise often exhausting workouts or heavy physical work with intense sweating, you have enough potassium coming from food. A good source of potassium is tea, natural coffee, cocoa powder, all nuts and sunflower seeds, raisins.
It is possible to use instead of sodium salt a food preventive salt containing potassium salts.
• The daily intake of potassium for an adult varies from 2 to 4 grams.
• With significant physical exertion - up to 5 grams.
• In total, the female potassium should be approximately 225 grams in the body, and 250 g in the male.
What Foods to Avoid When Taking Furosemide?
In the therapeutic diet, it is necessary to include foods that contain large amounts of potassium and magnesium. Proceeding from this, it is recommended to include in the menu dried apricots as a whole, and in the form of compotes. It is useful to combine the described diuretic with baked apples, which, like the dried apricots, can saturate the body with potassium and magnesium.
You should avoid alcohol and fatty foods. Alcohol increases the frequency and severity of the side effects of furosemide. If you use a diuretic at the same time and alcohol, then blood pressure may drop too. Symptoms of this: headache, dizziness, fainting, palpitations. Furosemide often causes orthostatic hypotension - dizziness with a sharp rise from sitting and lying down. Alcohol can enhance this side effect.
Alcohol dehydrates the body and displays useful minerals, like diuretics. Furosemide should be taken only in case of serious illnesses, in which drinking alcohol is completely prohibited. Even a small dose of alcohol will be harmful to you. For mild diseases that allow moderate consumption of alcohol, try to replace the loop diuretic with a more sparing drug or generally do without taking medications.